Seminar Series – 14 July (Fr)

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SymbNET Online Seminar Series

Monthly seminars on host-microbe symbiosis, genomics, and metabolomics, with two talks from SymbNET researchers.

The seminars are open and free to all, but registration is required.

Please register once for the entire seminar series.

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14th Jul 2023

14h00 WEST // 15h00 CEST

@FCG-IGC Friday seminar (Hybrid: in-person and online)

If you want to attend in person, but do not work at the IGC or ITQB campus, please register and send an email to [email protected]

 

Speaker: Paul Schultze-Lefert

Affiliation: MPI for Plant Breeding Research, Cologne, Germany

Title: Plant innate immunity and cell death mediated by intracellular NLR immune receptors

Abstract: Animal and plant immune systems use intracellular nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) to detect pathogens, resulting in the activation of immune responses that are often associated with localized host cell death. Whereas vertebrate NLRs detect evolutionarily conserved molecular patterns and have undergone comparatively little copy number expansion, plant NLRs detect virulence factors that have often diversified in plant pathogen populations, and thus plant NLRs have been subject to parallel diversification. Plant NLRs sense the presence of virulence factors with enzymatic virulence activity often indirectly through their modification of host target proteins. By contrast, phytopathogenic virulence factors without enzymatic activity are usually recognized by NLRs directly by their structure. Recent structural and biochemical analyses have shown that both indirect and direct recognition of plant pathogens trigger the oligomerization of plant NLRs into signaling active heterocomplexes. Assembly into three-layered ring-like structures has emerged as a common principle of NLR activation in plants and animals, but with distinct amino-terminal domains initiating different signaling pathways. I will discuss recent advances in understanding initiation of plant immune signaling triggered by activation of two major classes plant NLRs, containing either a N-terminal Toll/Interleukin 1 receptor (TIR) or a coiled-coil (CC) domain. I will discuss recent advances in understanding the initiation of plant immune signaling triggered by activation of two major classes of plant NLRs containing either an N-terminal Toll/Interleukin 1 receptor (TIR) or a coiled-coil domain (CC).